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'四环福瑞科仪科技（北京）发展有限公司LGJ-20G/30G/40G冻干机成功落户河南洛阳制药'

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'四环,福瑞科,仪,科技,北京,发展,有限公司,'

'四环福瑞科仪科技发展（北京）有限公司 摘 要：随着国民经济的发展和科学技术的进步，人们对身体健康要求也越来越高。药品作为保障人体健康的重要成分，随着社会生产技术的发展，其生产加工后的稳定性和活性也有了新要求。冷冻干燥技术作为药品加工生产后控制稳定性的主要技术，在目前的制药领域受到高度的关注和广泛的使用。但是由于其在应用中涉及到制冷与真空技术等多个门类和工作领域，因此在工作中还有待进一步的优化与改进。 冷冻干燥技术简称为冻干技术，药品的冷冻干燥就是把含有水分的药品溶液冷冻到冰点以下，使水转变成冰，然后在高真'

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'2020-07-31 22:04:35'

'2020-07-31 22:04:39'

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'<p>&nbsp;</p><p style="margin: 5px 0px;"><img width="80" height="80" title="1594863157572704.png" style="width: 80px; height: 80px; white-space: normal;" alt="1594863157572704.png" src="/uploads/allimg/20200731/1596203968972717.png" border="0" vspace="0"/><span style="font-size: 14px;"><span style="font-family: 宋体, SimSun;">四环福瑞科仪科技发展（北京）有限公司</span></span></p><p style="margin: 5px 0px;"><span style="font-size: 14px;"><span style="font-family: 宋体, SimSun;"><br/></span></span></p><p style="margin: 5px 0px; line-height: 24px;"><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">摘</span>&nbsp;<span style="font-family: 宋体;">要：随着国民经济的发展和科学技术的进步，人们对身体健康要求也越来越高。药品作为保障人体健康的重要成分，随着社会生产技术的发展，其生产加工后的稳定性和活性也有了新要求。冷冻干燥技术作为药品加工生产后控制稳定性的主要技术，在目前的制药领域受到高度的关注和广泛的使用。但是由于其在应用中涉及到制冷与真空技术等多个门类和工作领域，因此在工作中还有待进一步的优化与改进。</span></span></p><p style="margin: 5px 0px; line-height: 24px;"><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">冷冻干燥技术简称为冻干技术，药品的冷冻干燥就是把含有水分的药品溶液冷冻到冰点以下，使水转变成冰，然后在高真空条件下把冰转变成蒸汽从而除去结合水的干燥方法。在低温下冻干可以使被干燥的药品不容易接触到氧气而变质，并能使之因缺氧达到灭菌、抑制细菌产生的目的。冷冻时被干燥的药品可以在干燥后保持原状和色泽，彻底脱水的冻干药品适合长途运输和长期保存。所以在真空、低温下对药品冻干脱水的技术在医药制药领域广泛应用。下面从冷冻技术的发展史、特点、原理及过程、设备的简介四个方面对其在制药工艺中的应用进行简单分析。</span></span></p><p style="margin: 5px 0px; line-height: 24px;"><strong><span style="line-height: 28.5px; font-family: 宋体; font-size: 19px;"><span style="font-family: 宋体;">一、冷冻干燥技术的发展史</span></span></strong></p><p style="margin: 5px 0px; line-height: 24px;"><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">&nbsp; &nbsp; 冻干技术是在一八一三年被英国科学家华莱斯顿研制出来的，之后在一八九零年埃特曼使用这种方法查看组织以及细胞切片，研制出了生物产品的冷冻干燥技术；一九零九年沙克尔为了使物品能够存放更久的时间同时防止蛋白因为高温发生改变，对抗霉素、狂犬病毒以及菌种和其他生物产品使用了冷冻干燥技术；在一九三五年，冷冻干燥技术有了很大的进步，第一次进行冷冻技术的同时随之进行加热，极大地提升冷冻干燥的速度。在一九四零年，这种技术在军队中所运用，推动了冻干技术的发展。第二次世界大战之时，冷冻干燥技术在商业范围内第一次被使用，例如冷冻干燥菌类、培养基、维生素、药品、荷尔蒙、人血浆等等，这时这项技术才正在慢慢的成熟。</span></span></p><p style="margin: 5px 0px; line-height: 24px;"><img width="420" height="451" title="1596203264121026.jpg" style="width: 420px; height: 451px;" alt="制药1.jpg" src="/uploads/allimg/20200731/1596203969522954.jpg"/>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<span style="line-height: 24px; font-family: 宋体; font-size: 16px;">&nbsp;<img width="342" height="446" title="1596203293629343.jpg" style="width: 342px; height: 446px;" alt="制药4.jpg" src="/uploads/allimg/20200731/1596203969577444.jpg"/></span></p><p style="margin: 5px 0px; line-height: 24px;"><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">四环福瑞科仪科技发展（北京）有限公司正式落户河南洛阳制药，四环真空冷冻干燥机</span></span><span style="line-height: 24px; font-family: 宋体; font-size: 16px;">LGJ-20G/30G/40G</span><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">型号真空冷冻干燥机</span></span><span style="line-height: 24px; font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">制药过程。</span></span><span style="text-align: center; font-family: 宋体;">&nbsp;</span></p><p style="margin: 5px 0px; text-align: center;"><span style="font-family: 宋体; font-size: 16px;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<img width="590" height="765" title="1596203463178151.jpg" style="width: 590px; height: 765px;" alt="原为0.jpg" src="/uploads/allimg/20200731/1596203969649767.jpg"/></span></p><p style="margin: 5px 0px; text-align: center;"><span style="font-family: 宋体; font-size: 16px;">&nbsp;</span></p><p style="margin: 5px 0px; text-indent: 37px;"><span style="font-family: 宋体, SimSun;"><span style="font-size: 21px;">LGJ-20G/30G/40G</span><strong><span style="font-size: 21px;">技术特点：</span></strong></span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">1、控制软件系统为安卓系统，冻干过程均有可编程程序自动控制，可实时切换为人工操作，实现冻干过程全程参数控制，在运行过程中系统自动监控检测并记录储存相关数据，也可通过标配远程系统进行监控，储存多个固定或自定义程序，可数字密码签名；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">2、连续记录实时数据，绘制冻干曲线，每分钟存储一次数据，具备USB数据存储串口；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">3、控制系统人机界面设备符合NEMA（国际电气制造业协会）防护规定和欧洲CE电气认证标准；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">4、系统配有各种传感器，实时记录显示真空度、冷阱温度、物料温度、搁板温度，运行错误报警，可在运行过程中温度和压力出现异常时即时报警并主动保护运行安全稳定；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">5、冻干腔体内部圆角、表面粗糙度、搁板平整度、腔体内部材料均满足制药标准，光洁耐腐蚀且易清洁；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">6、冻干自动控制系统冻干过程升温和降温均采用PID控制，可自动实现对物料反复预冻、速冻和慢冻；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">7、中间介质循环技术：搁板梯度控温，特殊工艺流程制造保证板层温度均一、可控性强，板层平整，冷热量传导良好，提高冻干效率；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">8、外置冷阱提高设备的捕水能力，减少冻干过程中冷阱温度对物料的干扰，保证物料冻干质量一致和实验数据稳定，提高冻干效率，降低能源损耗；</span></p><p style="margin: 5px 0px 5px 16px; line-height: 29px; text-indent: 16px;"><span style="font-family: 宋体; font-size: 16px;">9、采用进口压缩机双机复叠制冷技术，国际标准绿色环保冷媒，制冷迅速，冷阱温度低，捕水能力强；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">10、具有自动化霜功能；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">11、复压掺气系统：减少样品二次污染，可回填氮气或惰性气体；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">12、压塞方式：手动或电动；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">13、提供洁净室安装解决方案；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">14、真空度全程自动控制，可选配真空度调节功能；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">15、选配共晶点测试功能，更好的优化样品升华工艺；</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">16、选配上位机控制。</span></p><p style="margin: 5px 0px 5px 32px; line-height: 29px; text-indent: 0px;"><span style="font-family: 宋体; font-size: 16px;"><span style="font-family: 宋体;">选配：多歧管挂瓶装置、冻干瓶（茄形瓶和广口瓶）、安瓿管冻干架、安瓿管封口器、西林瓶扎盖机、进口真空泵、高速真空泵油。</span></span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 达标冷阱温度： ≤-83℃ （空载，环境温度 ≤30℃）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 极限冷阱温度： ≤-86℃ （空载，环境温度 ≤25℃）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 达标真空度： ≤10Pa（空载）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 极限真空度： ≤1Pa（空载）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※搁板降温速率：20℃降至-40℃≤60min（空载）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※冷阱降温速率：20℃降至-40℃≤30min（空载）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※真空抽气速率：标准大气压降至10Pa≤20min（空载）</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 最大捕水量：8Kg</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※搁板尺寸：335mm×300mm</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※搁板控温范围：-50℃～+70℃</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※主机外形尺寸（长×宽×高）：700mm×800mm×1550mm</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※电源要求：AC380V 50Hz 三相五线制或AC220V 50Hz</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※总功率：3300W</span></p><p style="margin: 5px 0px; line-height: 29px; text-indent: 32px;"><span style="font-family: 宋体; font-size: 16px;">※ 适用环境：≤30℃</span></p><table cellspacing="0"><tbody><tr class="firstRow"><td width="141" valign="top" style="padding: 0px 7px; border: 1px solid windowtext; border-image: none;"><br/></td><td width="143" valign="top" style="border-width: 1px 1px 1px medium; border-style: solid solid solid none; border-color: windowtext windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">LGJ-20G</span></p></td><td width="143" valign="top" style="border-width: 1px 1px 1px medium; border-style: solid solid solid none; border-color: windowtext windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">LGJ-30G</span></p></td><td width="143" valign="top" style="border-width: 1px 1px 1px medium; border-style: solid solid solid none; border-color: windowtext windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">LGJ-40G</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">有效搁板面积</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">0.2㎡</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">0.3㎡</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">0.4㎡</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">可用搁板层</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">2</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">3</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">4</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">搁板层间距</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">143mm</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">90mm</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">65mm</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">φ22mm西林瓶（个）</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">440</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">660</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">880</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">φ16mm西林瓶（个）</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">820</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">1230</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">1640</span></p></td></tr><tr><td width="141" valign="top" style="border-width: medium 1px 1px; border-style: none solid solid; border-color: currentColor windowtext windowtext; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">整机重量</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">285㎏</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">295㎏</span></p></td><td width="143" valign="top" style="border-width: medium 1px 1px medium; border-style: none solid solid none; border-color: currentColor windowtext windowtext currentColor; padding: 0px 7px;"><p style="margin: 0px; padding: 0px; line-height: 29px;"><span style="font-family: 宋体; font-size: 16px;">305㎏</span></p></td></tr></tbody></table><p style="margin: 5px 0px;"><span style="font-family: 宋体; font-size: 16px;">&nbsp;</span></p><p style="margin: 5px 0px;"><span style="font-family: 黑体; font-size: 20px;">&nbsp;</span></p><p style="margin: 5px 0px;"><br style="color: rgb(0, 0, 0); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: sans-serif; font-size: 16px; font-style: normal; font-weight: 400; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; font-variant-ligatures: normal; font-variant-caps: normal; -webkit-text-stroke-width: 0px; text-decoration-style: initial; text-decoration-color: initial;"/></p><p>&nbsp;</p>'

'四环,福瑞科,仪,科技,北京,发展,有限公司,'

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'四环福瑞科仪科技（北京）发展有限公司LGJ-20G/30G/40G冻干机成功落户河南洛阳制药_工程案例_冻干机-北京四环冻干-真空冷冻干燥机-四环冻干机官网-实验室冻干机-化妆品冻干机'

'四环,福瑞科,仪,科技,北京,发展,有限公司'

'四环福瑞科仪科技发展（北京）有限公司 摘 要：随着国民经济的发展和科学技术的进步，人们对身体健康要求也越来越高。药品作为保障人体健康的重要成分，随着社会生产技术的发展，其生产加工后的稳定性和活性也有了新要求。冷冻干燥技术作为药品加工生产后控制稳定性的主要技术，在目前的制药领域受到高度的关注和广泛的使用。但是由于其在应用中涉及到制冷与真空技术等多个门类和工作领域，因此在工作中还有待进一步的优化与改进。 冷冻干燥技术简称为冻干技术，药品的冷冻干燥就是把含有水分的药品溶液冷冻到冰点以下，使水转变成冰，然后在高真'

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